{"id":20042,"date":"2023-02-28T13:03:15","date_gmt":"2023-02-28T12:03:15","guid":{"rendered":"https:\/\/www.innovationsforetagen.se\/?p=20042"},"modified":"2025-09-16T14:09:27","modified_gmt":"2025-09-16T12:09:27","slug":"innovation-inom-deep-brain-stimulation-ger-nytt-hopp-for-parkinsonspatienter","status":"publish","type":"post","link":"https:\/\/www.innovationsforetagen.se\/2023\/02\/innovation-inom-deep-brain-stimulation-ger-nytt-hopp-for-parkinsonspatienter\/","title":{"rendered":"Innovation inom Deep Brain Stimulation ger nytt hopp f\u00f6r Parkinsonspatienter"},"content":{"rendered":"

Avalon Innovation, ett stort industrikonsultf\u00f6retag i Sverige, har tillsammans med medicinteknikf\u00f6retaget Neuronano utvecklat en ny behandling f\u00f6r Parkinsons sjukdom med hj\u00e4lp av elektrodimplantat. Den nya tekniken ger en mer tr\u00e4ffs\u00e4ker behandling med f\u00e4rre biverkningar och v\u00e4ntas kunna testas p\u00e5 m\u00e4nniskor om tv\u00e5 \u00e5r. \u00a0<\/strong><\/p>\n\n

Parkinsons \u00e4r en sjukdom som drabbar omkring en procent av alla \u00f6ver 65 \u00e5r. Sjukdomsf\u00f6rloppet b\u00f6rjar med att kroppens f\u00f6rm\u00e5ga att producera dopamin f\u00f6rs\u00e4mras \u2013 en signalsubstans som spelar stor roll f\u00f6r hj\u00e4rnans motoriska funktion. Det finns i dag mediciner som p\u00e5 konstgjord v\u00e4g \u00f6kar dopaminniv\u00e5n i hj\u00e4rnan, men n\u00e4r sjukdomen fortskrider \u00e4r det inte m\u00f6jligt att kompensera f\u00f6rlusten av dopamin genom att \u00f6ka dosen av dessa mediciner.<\/p>\n\n\n\n

F\u00e4rre bieffekter och mer tr\u00e4ffs\u00e4ker behandling<\/strong>
Den nya behandlingen som utvecklats av Neuronano i samarbete med Avalon Innovation g\u00e5r ut p\u00e5 att implantera en matris av extremt tunna och flexibla mikroelektroder (tjocklek ca 1\/3 av ett h\u00e5rstr\u00e5) i hj\u00e4rnan f\u00f6r att stimulera de omr\u00e5den som drabbats av Parkinsons sjukdom. Mikroelektrodernas signaler kan bidra till att mildra symptom som skakningar och stelhet.<\/p>\n\n\n\n

Konventionella elektroder \u00e4r ca 50 g\u00e5nger tjockare och f\u00e4sts i skallbenet. Eftersom hj\u00e4rnan r\u00f6r sig kan det uppkomma ett ”skav” som f\u00f6rs\u00e4mrar stimuleringen \u00f6ver tid.  Den nya metodens mikroelektrodmatris ger en betydligt mer precis stimulering bland annat genom att mikroelektroderna f\u00f6ljer hj\u00e4rnans r\u00f6relse p\u00e5 grund av sin flexibilitet.<\/p>\n\n\n\n

Teknologin, som anv\u00e4nder en gelbaserad b\u00e4rare f\u00f6r att f\u00f6ra in dem kontrollerat i hj\u00e4rnan. V\u00e4l p\u00e5 plats bryts gelen ner och l\u00e4mnar bara de tunna mikroelektroderna kvar.<\/p>\n\n\n\n

– Resan med att utveckla behandlingen b\u00f6rjade l\u00e5ngt innan kommersialiseringsprocessen. Nu handlar det om att g\u00e5 fr\u00e5n prekliniskt stadie till faktisk anv\u00e4ndning. Vi hoppas p\u00e5 att produkten testas p\u00e5 m\u00e4nniska inom tv\u00e5 \u00e5r, s\u00e4ger J\u00f6rgen Hager, CTO Neuronano. <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Medtech-branschens regleringar st\u00e4ller h\u00f6ga krav<\/strong>
Behandlingsmetoden befinner sig f\u00f6r n\u00e4rvarande i den prekliniska fasen av testning. P\u00e5 grund av hur tekniskt avancerad och k\u00e4nslig metoden \u00e4r har den en h\u00f6g regulatorisk klassificering. Det inneb\u00e4r att varje steg i test- och utvecklingsprocessen m\u00e5ste kvalitetsgranskas, testas och dokumenteras.<\/p>\n\n\n\n

– Vi har visat ”proof of concept” p\u00e5 b\u00e5de r\u00e5ttor och minigrisar, som visat sig fungera helt enligt plan. Med hj\u00e4lp av v\u00e5r metod har vi kunnat eliminera medicinskt genererade Parkinsons-liknande symptom, s\u00e4ger J\u00f6rgen Hager.<\/p>\n\n\n\n

Avalon Innovation kom in i processen f\u00f6r att st\u00f6dja Neuronano i att g\u00e5 fr\u00e5n forskningsprojekt till en kommersiellt g\u00e5ngbar produkt. J\u00f6rgen ber\u00e4ttar hur hela processen kr\u00e4ver mycket utf\u00f6rlig dokumentation d\u00e4r alla beslut och uppt\u00e4ckter m\u00e5ste kunna sp\u00e5ras. Det har beh\u00f6vt ske en f\u00f6rflyttning i organisationskulturen p\u00e5 Neuronano, d\u00e4r forskarna beh\u00f6vt v\u00e4nja sig att dokumentera ner alla resultat, b\u00e5de fram- och motg\u00e5ngar, i processen. I detta arbete har Avalon Innovation varit en mycket v\u00e4rdefull partner med stor och bred kompetens.<\/p>\n\n\n\n

– Vi \u00e4r en stor grupp seniora experter inom produkt- och systemutveckling, med bakgrund och spetskompetens inom en m\u00e4ngd olika discipliner. F\u00f6r teamet p\u00e5 Neuronano har v\u00e5r erfarenhet inom produktutveckling med en definierad arbetsmetodik, samt att ta de unika behoven de funnit till tekniska l\u00f6sningar varit en viktig faktor. Att f\u00e5 arbeta med teknik som hj\u00e4lper m\u00e4nniskor till ett b\u00e4ttre liv, \u00e4r otroligt motiverande, s\u00e4ger Helene H\u00f6gberg, vd p\u00e5 Avalon Innovation.<\/p>\n\n\n\n\n\n

\n \n L\u00e4s alla case h\u00e4r\n \n \n \n \n\n<\/svg>\n\n \n <\/a>\n \n\n\n\n\n\n\n

\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Parkinsons \u00e4r en sjukdom som drabbar omkring en procent av alla \u00f6ver 65 \u00e5r. Sjukdomsf\u00f6rloppet b\u00f6rjar med att kroppens f\u00f6rm\u00e5ga att producera dopamin f\u00f6rs\u00e4mras \u2013 en signalsubstans som spelar stor roll f\u00f6r hj\u00e4rnans motoriska funktion. …<\/p>\n","protected":false},"author":127,"featured_media":20045,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[75],"tags":[430],"article_type":[],"agreement":[],"for-members":[],"class_list":["post-20042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-forskning-och-innovation","tag-case"],"acf":[],"yoast_head":"\nInnovation inom Deep Brain Stimulation ger nytt hopp f\u00f6r Parkinsonspatienter - Innovations\u00adf\u00f6retagen<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.innovationsforetagen.se\/2023\/02\/innovation-inom-deep-brain-stimulation-ger-nytt-hopp-for-parkinsonspatienter\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Innovation inom Deep Brain Stimulation ger nytt hopp f\u00f6r Parkinsonspatienter - Innovations\u00adf\u00f6retagen\" \/>\n<meta property=\"og:description\" content=\"Parkinsons \u00e4r en sjukdom som drabbar omkring en procent av alla \u00f6ver 65 \u00e5r. 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